Complement Activation and Complement-Dependent Inflammation by Neisseria meningitidis Are Independent of Lipopolysaccharide
نویسندگان
چکیده
منابع مشابه
Complement activation and complement-dependent inflammation by Neisseria meningitidis are independent of lipopolysaccharide.
Fulminant meningococcal sepsis has been termed the prototypical lipopolysaccharide (LPS)-mediated gram-negative septic shock. Systemic inflammation by activated complement and cytokines is important in the pathogenesis of this disease. We investigated the involvement of meningococcal LPS in complement activation, complement-dependent inflammatory effects, and cytokine or chemokine production. W...
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Finding factors that control complement (C) components deposition on bacterial cells is the way to explain the sophisticated mechanism of bacteraemia. Lipopolysaccharide (LPS, endotoxin) is a surface antigen found in the cell walls of Gram-negative bacteria, such as Salmonella [1]. LPS action on the human body is often considered in the context of sepsis, which is characterized by an excessive ...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2004
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.72.6.3344-3349.2004